Optogenetic investigation of neural circuits in vivo.
Trends Mol Med
; 17(4): 197-206, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21353638
ABSTRACT
The recent development of light-activated optogenetic probes allows for the identification and manipulation of specific neural populations and their connections in awake animals with unprecedented spatial and temporal precision. This review describes the use of optogenetic tools to investigate neurons and neural circuits in vivo. We describe the current panel of optogenetic probes, methods of targeting these probes to specific cell types in the nervous system, and strategies of photostimulating cells in awake, behaving animals. Finally, we survey the application of optogenetic tools to studying functional neuroanatomy, behavior and the etiology and treatment of various neurological disorders.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Opsinas
/
Luz
/
Proteínas Luminiscentes
/
Sistema Nervioso
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos