Mutated beta-catenin evades a microRNA-dependent regulatory loop.
Proc Natl Acad Sci U S A
; 108(12): 4840-5, 2011 Mar 22.
Article
en En
| MEDLINE
| ID: mdl-21383185
ABSTRACT
hsa-mir-483 is located within intron 2 of the IGF2 gene. We have previously shown oncogenic features of miR-483-3p through cooperation with IGF2 or by independently targeting the proapoptotic gene BBC3/PUMA. Here we demonstrate that expression of miR-483 can be induced independently of IGF2 by the oncoprotein ß-catenin through an interaction with the basic helix-loop-helix protein upstream stimulatory transcription factor 1. We also show that ß-catenin itself is a target of miR-483-3p, triggering a negative regulatory loop that becomes ineffective in cells harboring an activating mutation of ß-catenin. These results provide insights into the complex regulation of the IGF2/miR-483 locus, revealing players in the ß-catenin pathway.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
MicroARNs
/
Beta Catenina
/
Mutación
Límite:
Humans
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos