Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis.
Eur J Neurosci
; 33(6): 1160-9, 2011 Mar.
Article
en En
| MEDLINE
| ID: mdl-21395860
ABSTRACT
Adult neurogenesis is a sophisticated biological process whose function has remained a mystery to neuroscience researchers. To address this question, a number of unique modeling studies have explored the computational implications of adding new neurons to the adult dentate gyrus. Models of neurogenesis fall into two broad categories abstract models that explore the function of new neurons in simple networks, and biologically based models that investigate the role of new neurons in networks based on the anatomy of the hippocampus. In this review, we summarize the strategies and results of these different modeling approaches, and we discuss their conclusions and limitations in the face of new biological findings.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Simulación por Computador
/
Neurociencias
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Células Madre Adultas
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Neurogénesis
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Modelos Neurológicos
/
Neuronas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Eur J Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos