Efficacy and safety of administration of oral iron chelator deferiprone in patients with early myelodysplastic syndrome.
Hemoglobin
; 35(3): 217-27, 2011.
Article
en En
| MEDLINE
| ID: mdl-21599434
ABSTRACT
Forty-eight patients with early myelodysplastic syndrome (MDS) without excess of blasts, with average initial serum ferritin levels of 2739.5 µg/L (range 825-11287 µg/L), were treated with deferiprone (L1) in a daily dose of 40-90 mg/kg. Median duration of chelation treatment was 10.9 months (range 4-24 months). Chelation was effective (maintained or decreased iron stores) in 16 out of 22 patients (73%) with serum ferritin levels <2000 µg/L in contrast to only 12 out of 26 patients with serum ferritin levels >2000 µg/L. Combination of L1 with recombinant human erythropoietin (rHuEPO) (30-40 kU/week) resulted in effective chelation in five additional patients with serum ferritin levels >3000 µg/L. Incidence of adverse effects was comparable to that in thalassemic patients. Gastrointestinal symptoms represented the most frequent adverse effect of L1 therapy (37.5% of patients) that limited an effective escalation of the daily dose of the drug and led to discontinuation of the treatment for six patients. A decreased number of granulocytes was observed in five (13%) patients and agranulocytosis occurred in two patients (4%). Granulocyte counts were restored after cessation of L1 treatment and administration of granulocyte colony stimulating factor (G-CSF) in all but one patient. Administration of L1 in a daily dose of at least 75 mg/kg may represent an alternative approach in treatment of mild and moderate iron overload in MDS patients who cannot be treated with deferasirox (DFRA) or deferoxamine (DFO).
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piridonas
/
Síndromes Mielodisplásicos
/
Quelantes del Hierro
/
Sobrecarga de Hierro
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hemoglobin
Año:
2011
Tipo del documento:
Article
País de afiliación:
República Checa