Pyridazine-derived γ-secretase modulators.
Bioorg Med Chem Lett
; 21(13): 4016-9, 2011 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-21636276
ABSTRACT
SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aß42 and Aß40, and maintain the levels of total Aß. Furthermore, 25 demonstrated excellent pharmacokinetic parameters as well as good CNS penetration in the rat.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piridazinas
/
Secretasas de la Proteína Precursora del Amiloide
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
China