Human urinary excretion profile after smoking and oral administration of [14C]delta 1-tetrahydrocannabinol.
J Anal Toxicol
; 14(3): 176-80, 1990.
Article
en En
| MEDLINE
| ID: mdl-2165199
ABSTRACT
The urinary excretion profiles of delta 1-tetrahydrocannabinol (delta 1-THC) metabolites have been evaluated in two chronic and two naive marijuana users after smoking and oral administration of [14C]delta 1-THC. Urine was collected for five days after each administration route and analyzed for total delta 1-THC metabolites by radioactivity determination, for delta 1-THC-7-oic acid by high-performance liquid chromatography, and for cross-reacting cannabinoids by the EMIT d.a.u. cannabinoid assay. The average urinary excretion half-life of 14C-labeled delta 1-THC metabolites was calculated to be 18.2 +/- 4.9 h (+/- SD). The excretion profiles of delta 1-THC-7-oic acid and EMIT readings were similar to the excretion profile of 14C-labeled metabolites in the naive users. However, in the chronic users the excretion profiles of delta 1-THC-7-oic acid and EMIT readings did not resemble the radioactive excretion due to the heavy influence from previous Cannabis use. Between 8-14% of the radioactive dose was recovered in the urine in both user groups after oral administration. Lower urinary recovery was obtained both in the chronic and naive users after smoking--5 and 2%, respectively.
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Banco de datos:
MEDLINE
Asunto principal:
Dronabinol
/
Fumar Marihuana
Límite:
Humans
Idioma:
En
Revista:
J Anal Toxicol
Año:
1990
Tipo del documento:
Article
País de afiliación:
Suecia