New approach for graded compression spinal cord injuries in Rhesus macaque: method feasibility and preliminary observations.
J Med Primatol
; 40(6): 401-13, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-21732951
ABSTRACT
BACKGROUND:
Current models of spinal cord injury (SCI) have been ineffective for translational research. Primate blunt SCI, which more closely resembles human injury, could be a promising model to fill this gap.METHODS:
Graded compression SCI was produced by inflating at T9 an epidural balloon as a function of spinal canal dimensions in a non-uniform group of monkeys.RESULTS:
Sham injury and cord compression by canal invasion of 50-75% produced minimal morpho-functional alterations, if at all. Canal invasion of 90-100% resulted in proportional functional deficits. Unexpectedly, these animals showed spontaneous gradual recovery over a 12-week period achieving quadruped walking, although with persistent absence of foot grasping reflex. Histopathology revealed predominance of central cord damage that correlated with functional status.CONCLUSIONS:
Our preliminary results suggest that this model could potentially be a useful addition to translational work, but requires further validation by including animals with permanent injuries and expansion of replicates.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Médula Espinal
/
Compresión de la Médula Espinal
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Traumatismos de la Médula Espinal
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Cirugía Veterinaria
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Modelos Animales de Enfermedad
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Macaca mulatta
Tipo de estudio:
Evaluation_studies
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
J Med Primatol
Año:
2011
Tipo del documento:
Article
País de afiliación:
México