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Real-time FDG PET guidance during biopsies and radiofrequency ablation using multimodality fusion with electromagnetic navigation.
Venkatesan, Aradhana M; Kadoury, Samuel; Abi-Jaoudeh, Nadine; Levy, Elliot B; Maass-Moreno, Roberto; Krücker, Jochen; Dalal, Sandeep; Xu, Sheng; Glossop, Neil; Wood, Bradford J.
Afiliación
  • Venkatesan AM; Center for Interventional Oncology, Radiology and Imaging Sciences, National Institutes of Health, 10 Center Dr, Bldg 10, Room 1C369, MSC 1182, Bethesda, MD 20892, USA. VenkatesanA@cc.nih.gov
Radiology ; 260(3): 848-56, 2011 Sep.
Article en En | MEDLINE | ID: mdl-21734159
PURPOSE: To assess the feasibility of combined electromagnetic device tracking and computed tomography (CT)/ultrasonography (US)/fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) fusion for real-time feedback during percutaneous and intraoperative biopsies and hepatic radiofrequency (RF) ablation. MATERIALS AND METHODS: In this HIPAA-compliant, institutional review board-approved prospective study with written informed consent, 25 patients (17 men, eight women) underwent 33 percutaneous and three intraoperative biopsies of 36 FDG-avid targets between November 2007 and August 2010. One patient underwent biopsy and RF ablation of an FDG-avid hepatic focus. Targets demonstrated heterogeneous FDG uptake or were not well seen or were totally inapparent at conventional imaging. Preprocedural FDG PET scans were rigidly registered through a semiautomatic method to intraprocedural CT scans. Coaxial biopsy needle introducer tips and RF ablation electrode guider needle tips containing electromagnetic sensor coils were spatially tracked through an electromagnetic field generator. Real-time US scans were registered through a fiducial-based method, allowing US scans to be fused with intraprocedural CT and preacquired FDG PET scans. A visual display of US/CT image fusion with overlaid coregistered FDG PET targets was used for guidance; navigation software enabled real-time biopsy needle and needle electrode navigation and feedback. RESULTS: Successful fusion of real-time US to coregistered CT and FDG PET scans was achieved in all patients. Thirty-one of 36 biopsies were diagnostic (malignancy in 18 cases, benign processes in 13 cases). RF ablation resulted in resolution of targeted FDG avidity, with no local treatment failure during short follow-up (56 days). CONCLUSION: Combined electromagnetic device tracking and image fusion with real-time feedback may facilitate biopsies and ablations of focal FDG PET abnormalities that would be challenging with conventional image guidance.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biopsia / Técnica de Sustracción / Ablación por Catéter / Cirugía Asistida por Computador / Tomografía de Emisión de Positrones / Neoplasias Hepáticas Tipo de estudio: Guideline / Observational_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Radiology Año: 2011 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biopsia / Técnica de Sustracción / Ablación por Catéter / Cirugía Asistida por Computador / Tomografía de Emisión de Positrones / Neoplasias Hepáticas Tipo de estudio: Guideline / Observational_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Radiology Año: 2011 Tipo del documento: Article País de afiliación: Estados Unidos