Multipurpose prevention technologies: biomedical tools to prevent HIV-1, HSV-2, and unintended pregnancies.
Infect Dis Obstet Gynecol
; 2011: 1-10, 2011.
Article
en En
| MEDLINE
| ID: mdl-21836811
ABSTRACT
Statistics clearly show an unmet need for highly effective contraception, especially in less developed countries. Many of these countries are at the core of the HIV/AIDS epidemic and show very high prevalence rates for other sexually transmitted infections (STIs) such as that caused by HSV-2. A woman at risk of unintended pregnancy due to unprotected intercourse is also at risk for HIV/STI. Owing to their causative interrelationship, combining protection against these conditions will result in enhanced prevention and health benefits. Existing multipurpose prevention modalities such as condoms and physical barriers, albeit efficacious, face cultural hurdles that have so far hindered their widespread use. Success has recently been demonstrated in large clinical trials, demonstrating proof of concept of microbicides in reducing the incidence of HIV-1 and HSV-2 among at-risk populations. The challenge heretofore is to refine these products to make them more potent, convenient, accessible, and acceptable. Potent antiviral drugs released topically in the female reproductive tract by innovative delivered systems and formulations will provide safe, effective, and acceptable multipurpose prevention tools. This paper provides an overview of existing and novel approaches to multipurpose prevention strategies.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
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Infecciones por VIH
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Embarazo no Planeado
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Herpes Simple
Tipo de estudio:
Risk_factors_studies
Límite:
Female
/
Humans
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Pregnancy
Idioma:
En
Revista:
Infect Dis Obstet Gynecol
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
GINECOLOGIA
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OBSTETRICIA
Año:
2011
Tipo del documento:
Article