Fragment-based development of HCV protease inhibitors for the treatment of hepatitis C.
Curr Comput Aided Drug Des
; 8(1): 55-61, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-22242797
ABSTRACT
A novel computational technology based on fragmentation of the chemical compounds has been used for the fast and efficient prediction of activities of prospective protease inhibitors of the hepatitis C virus. This study spans over a discovery cycle from the theoretical prediction of new HCV NS3 protease inhibitors to the first cytotoxicity experimental tests of the best candidates. The measured cytotoxicity of the compounds indicated that at least two candidates would be suitable further development of drugs.
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Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Péptido Hidrolasas
/
Inhibidores de Proteasas
/
Hepacivirus
/
Relación Estructura-Actividad Cuantitativa
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Curr Comput Aided Drug Des
Asunto de la revista:
FARMACOLOGIA
/
INFORMATICA MEDICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estonia