The relevance of BRCA genetics to prostate cancer pathogenesis and treatment.
Clin Adv Hematol Oncol
; 9(10): 748-55, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-22252577
ABSTRACT
The breast cancer susceptibility genes 1 (BRCA1) and 2 (BRCA2) are cellular proteins involved in DNA repair. They are normally expressed in the breast, ovaries, prostate, and other tissues. Their germline mutation is the cause of hereditary breast-ovarian cancer syndromes. BRCA mutation carriers are also susceptible to other cancers, notably prostate cancer. In this article, we review the role of BRCA genes in the pathogenesis and clinical course of prostate cancer. We also discuss the molecular mechanisms of action and the therapeutic implications of BRCA germline mutations.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
ADN de Neoplasias
/
Adenocarcinoma
/
Proteína BRCA1
/
Proteína BRCA2
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Clin Adv Hematol Oncol
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos