Release of filamentous and spherical influenza A virus is not restricted by tetherin.
J Gen Virol
; 93(Pt 5): 963-969, 2012 May.
Article
en En
| MEDLINE
| ID: mdl-22258861
ABSTRACT
The cellular protein tetherin is thought to act as a 'leash' that anchors many enveloped viruses to the plasma membrane and prevents their release. We found that replication of multiple strains of influenza A virus was generally insensitive to alteration of tetherin levels, as assessed by output titre or scanning electron microscopy of cell-associated virions. This included human, swine, avian and equine isolates, strains that form filamentous or spherical particles and viruses that lack the M2 or NS1 proteins. Levels of cell-surface tetherin were not reduced by influenza infection, but tetherin and the viral haemagglutinin co-localized on the plasma membrane. However, tetherin could not be detected in filamentous virions, suggesting that influenza may possess a mechanism to exclude it from virions. Overall, if influenza does encode a specific antagonist of tetherin, it is not M2 or NS1 and we find no evidence for a role in host range specificity.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
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Antígenos CD
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Interacciones Huésped-Patógeno
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Liberación del Virus
Límite:
Animals
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Humans
Idioma:
En
Revista:
J Gen Virol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Reino Unido