Statin treatment for coronary artery plaque composition based on intravascular ultrasound radiofrequency data analysis.
Am Heart J
; 163(2): 191-9.e1, 2012 Feb.
Article
en En
| MEDLINE
| ID: mdl-22305836
ABSTRACT
BACKGROUND:
Systemic therapy with statin has been shown to lower the risk of coronary events; however, the in vivo effects of statin therapy on plaque volume and composition are less understood.METHODS:
We conducted a prospective, open-labeled, randomized, multicenter study in 11 centers in Japan. A total of 164 patients were randomized to receive either 4 mg/d of pitavastatin (intensive lipid-lowering therapy) or 20 mg/d of pravastatin (moderate lipid-lowering therapy). Analyzable intravascular ultrasound data were obtained for 119 patients at baseline and at 8-month follow-up. The primary end point was the difference of volume changes in each of the 4 main plaque components (fibrosis, fibrofatty, calcium, and necrosis), assessed by virtual histology intravascular ultrasound, between the 2 groups.RESULTS:
The mean low-density lipoprotein cholesterol level at follow-up was significantly lower in the pitavastatin than in the pravastatin group (74 vs 95 mg/dL, P < .0001). During the 8-month follow-up period, statin therapy reduced the absolute and relative amount of fibrofatty component (pitavastatin from 1.09 to 0.81 mm(3)/mm, P = .001; pravastatin from 1.05 to 0.83 mm(3)/mm, P = .0008) and increased in the amount of calcium (pitavastatin from 0.42 to 0.55 mm(3)/mm, P < .0001; pravastatin from 0.44 to 0.55 mm(3)/mm, P = .005), whereas volume changes in both plaque components were not statistically different between the 2 groups.CONCLUSIONS:
Both pitavastatin and pravastatin altered coronary artery plaque composition by significantly decreasing the fibrofatty plaque component and increasing the calcified plaque component.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de la Arteria Coronaria
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Ultrasonografía Intervencional
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Inhibidores de Hidroximetilglutaril-CoA Reductasas
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Vasos Coronarios
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Placa Aterosclerótica
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Am Heart J
Año:
2012
Tipo del documento:
Article
País de afiliación:
Japón