Radiation-induced carotid stenotic lesions have a more stable phenotype than de novo atherosclerotic plaques.
Eur J Vasc Endovasc Surg
; 43(6): 643-8, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22436263
ABSTRACT
OBJECTIVE:
To identify plaque characteristics of carotid artery radiation-induced stenosis. MATERIALS ANDMETHODS:
Nineteen carotid plaques were obtained during carotid endarterectomy (CEA) in 17 consecutive patients with prior cervical radiation therapy (XRT) (median interval 10 years) and compared with 95 matched control carotid plaques of patients without a history of XRT. The following histopathological factors were assessed calcification, collagen, macrophages, smooth muscle cells, atheroma, microvessels and intraplaque haemorrhage. Association of individual histological parameters with XRT plaque was analysed through a multivariable regression model.RESULTS:
Less infiltration of macrophages (6/19 versus 60/95, adjusted p = 0.003) and a smaller lipid core size (Atheroma >10% 10/19 versus 80/95, adjusted p = 0.006) were independently associated with XRT plaque, compared to non-XRT plaques.CONCLUSIONS:
Carotid stenotic lesions in patients with previous cervical radiation are less inflammatory and more fibrotic than carotid atherosclerotic lesions in non-radiated patients.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Traumatismos por Radiación
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Arterias Carótidas
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Estenosis Carotídea
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Placa Aterosclerótica
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged80
País/Región como asunto:
Europa
Idioma:
En
Revista:
Eur J Vasc Endovasc Surg
Asunto de la revista:
ANGIOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Países Bajos