[Is the use of vitamin K antagonists harmful in patients with CDK?]. / Anticoagulants de type antivitamines K: effets délétères potentiels chez les patients avec une IRC.
Rev Med Suisse
; 8(330): 462-5, 2012 Feb 29.
Article
en Fr
| MEDLINE
| ID: mdl-22452132
ABSTRACT
As chronic kidney disease (CKD) is a contraindication to the use of the new anticoagulants, the vitamin K antagonists (VKA) are still valid in patients with CKD, though their use may be harmful. During overanticoagulation, some patients can develop acute kidney injury (AKI), especially those with CKD, by obstruction of the renal tubules and Bowman's spaces by erythrocytes. In addition, VKA increase atherogenesis through vitamin K deficiency, which is essential for the carboxylation of proteins that inhibit calcification of vessels. Eventually, hemodialysed patients under VKA have an increased risk of stroke, especially those over 75 years of age. Therefore anticoagulation with VKA in patients with CKD should be carefully implemented and its monitoring more frequent than in non-CKD patients.
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Banco de datos:
MEDLINE
Asunto principal:
Vitamina K
/
Trastornos de la Coagulación Sanguínea
/
Insuficiencia Renal Crónica
/
Lesión Renal Aguda
/
4-Hidroxicumarinas
/
Indenos
Tipo de estudio:
Evaluation_studies
Límite:
Humans
Idioma:
Fr
Revista:
Rev Med Suisse
Asunto de la revista:
MEDICINA
Año:
2012
Tipo del documento:
Article