A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers.
Mult Scler
; 18(12): 1797-800, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-22457344
ABSTRACT
Although vitamin D deficiency is considered an environmental factor in multiple sclerosis (MS), the immunological and clinical effects of vitamin D supplementation remain unclear. We performed a pilot study of the immunomodulatory effects of vitamin D in healthy individuals (n=4), who took 5000-10,000 IU/day of vitamin D over 15 weeks. After 15 weeks of vitamin D supplementation, serum 25(OH) vitamin D levels rose significantly from baseline, with a corresponding increase in IL-10 production by peripheral blood mononuclear cells and a reduced frequency of Th17 cells. These data provide a strong rationale for randomised trials to assess the clinical effects of vitamin D supplementation in MS.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vitamina D
/
Vitaminas
/
Leucocitos Mononucleares
Tipo de estudio:
Clinical_trials
Límite:
Humans
Idioma:
En
Revista:
Mult Scler
Asunto de la revista:
NEUROLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Irlanda