Study on the interference of rat feed to pharmacokinetics of flavonoids.
Zhong Yao Cai
; 34(12): 1906-11, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-22500429
ABSTRACT
OBJECTIVE:
To investigate the interference of rat feed to pharmacokinetic of flavonoids.METHODS:
Flavonoids in rat feed and plasma samples were separated by rapid resolution reversed-phase HPLC and characterized by LC-ESI-MS/MS analysis with an electrospray ionization source (ESI) and a triple quadrupole analyzer by fragmentation pattern.RESULTS:
Five Citrus flavonoids (naringin, naringenin, quercetin, hesperidin and hesperetin) and two soybean isoflavonoids (daizin,daidzein) were identified in common formula rat feed. The presence of these flavonoids in plasma from rats receiving the feed was also confirmed.CONCLUSION:
The results showed the flavonoids in animal food might interfere with pharmacological and pharmacokinetic study of foreign natural compounds. This paper could be taken as a reference to pharmacological and pharmacokinetic studies of all the related substances.
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Banco de datos:
MEDLINE
Asunto principal:
Cromatografía Liquida
/
Flavanonas
/
Isoflavonas
/
Alimentación Animal
Límite:
Animals
Idioma:
En
Revista:
Zhong Yao Cai
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2011
Tipo del documento:
Article
País de afiliación:
China