Incidence of deep sternal wound infection is not reduced with autologous platelet rich plasma in high-risk cardiac surgery patients.
Thorac Cardiovasc Surg
; 61(3): 180-4, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-22547304
ABSTRACT
BACKGROUND:
Deep sternal wound infections (DSWI) remain a devastating complication in cardiac surgery applying full sternotomy. As the risk profile in cardiac surgery changed toward an older and sicker population, the incidence of DSWI increases. Platelet rich plasma (PRP) holds promise in tissue regeneration with respect to bone regeneration, reduction of bleeding, and accelerated wound healing. The effect of PRP on DSWI was investigated in high-risk patients undergoing cardiac surgery with full sternotomy.METHODS:
196 consecutive patients at risk of DSWI were randomized to application of autologous PRP before sternal wiring (n = 97) or control (n = 99). All patients underwent cardiac surgery on cardiopulmonary bypass with cardioplegic cardiac arrest. Endpoint was occurrence of DSWI requiring revision surgery.RESULTS:
Demographic, intraoperative, and perioperative variables as well as risk factors were comparable between groups. Incidence of DSWI was not different between the PRP-group and the control-group (6/97 (6.2%) vs. 3/99 (3.0%); n.s.).CONCLUSIONS:
Local application of autologous PRP in cardiac surgery patients with full sternotomy at high risk for sternal complications did not reduce the incidence of DSWI.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infección de la Herida Quirúrgica
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Cicatrización de Heridas
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Regeneración Ósea
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Isquemia Miocárdica
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Plasma Rico en Plaquetas
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Esternotomía
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Procedimientos Quirúrgicos Cardíacos
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Thorac Cardiovasc Surg
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania