Enamino-oxindole HIV protease inhibitors.
Bioorg Med Chem Lett
; 22(15): 5078-83, 2012 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-22749283
ABSTRACT
We have designed and synthesized a series of HIV protease inhibitors (PIs) with enamino-oxindole substituents optimized to interact with the S2' subsite of the HIV protease binding pocket. Several of these inhibitors have sub-nanomolar K(i) and antiviral IC(50) in the low nM range against WT HIV and against a panel of multi-drug resistant (MDR) strains.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteasa del VIH
/
VIH-1
/
Inhibidores de la Proteasa del VIH
/
Indoles
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos