In vivo biomechanical stability of osseointegrating mesoporous TiO(2) implants.
Acta Biomater
; 8(12): 4438-46, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-22842030
ABSTRACT
Mesoporous materials are of high interest as implant coatings to receive an enhanced osseointegration. In this study, titanium implants coated with mesoporous TiO(2) thin films have been evaluated both in vitro and in vivo. Material characterization showed that, with partly crystalline TiO(2) (anatase), long-range-ordered hydrophilic mesoporous thin films with a pore size of 6nm were obtained. Evaluation of the mechanical resistance showed that the films were robust enough to withstand the standard implantation procedure. In vitro apatite formation was studied using simulated body fluids, showing that the pores are accessible for ions and that formation of apatite was increased due to the presence of the mesopores. An in vivo study using a rabbit model was executed in which the removal torque and histomorphometry were evaluated. The results show that the biomechanical stability of the TiO(2) coating was unaffected by the presence of mesopores and that osseointegration was achieved without any signs of inflammation.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Titanio
/
Ensayo de Materiales
/
Oseointegración
/
Sustitutos de Huesos
Límite:
Animals
Idioma:
En
Revista:
Acta Biomater
Año:
2012
Tipo del documento:
Article
País de afiliación:
Suecia