zCall: a rare variant caller for array-based genotyping: genetics and population analysis.
Bioinformatics
; 28(19): 2543-5, 2012 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-22843986
ABSTRACT
SUMMARY:
zCall is a variant caller specifically designed for calling rare single-nucleotide polymorphisms from array-based technology. This caller is implemented as a post-processing step after a default calling algorithm has been applied. The algorithm uses the intensity profile of the common allele homozygote cluster to define the location of the other two genotype clusters. We demonstrate improved detection of rare alleles when applying zCall to samples that have both Illumina Infinium HumanExome BeadChip and exome sequencing data available.AVAILABILITY:
http//atguweb.mgh.harvard.edu/apps/zcall. CONTACT bneale@broadinstitute.org SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Algoritmos
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Programas Informáticos
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Polimorfismo de Nucleótido Simple
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Técnicas de Genotipaje
Límite:
Humans
Idioma:
En
Revista:
Bioinformatics
Asunto de la revista:
INFORMATICA MEDICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos