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The role of the Janus kinase family/signal transducer and activator of transcription signaling pathway in fibrotic renal disease.
Matsui, Futoshi; Meldrum, Kirstan K.
Afiliación
  • Matsui F; Department of Urology, University of Florida School of Medicine, Gainesville, Florida 32610, USA.
J Surg Res ; 178(1): 339-45, 2012 Nov.
Article en En | MEDLINE | ID: mdl-22883438
ABSTRACT
Over the past several years, a number of cytokines and growth factors including transforming growth factor ß1, tumor necrosis factor α, and angiotensin II have been shown to play a crucial role in renal fibrosis. The Janus kinase family (JAK) and signal transducers and activators of transcription (STATs) constitute one of the primary signaling pathways that regulate cytokine expression, and the JAK/STAT signaling pathway has increasingly been implicated in the pathophysiology of renal disease. This review examines the role of the JAK/STAT signaling pathway in fibrotic renal disease. The JAK/STAT signaling pathway is activated in a variety of renal diseases and has been implicated in the pathophysiology of renal fibrosis. Experimental evidence suggests that inhibition of the JAK/STAT signaling pathway, in particular JAK2 and STAT3, may suppress renal fibrosis and protect renal function. However, it is incompletely understood which cells activate the JAK/STAT signaling pathway and which JAK/STAT signaling pathway is activated in each renal disease. Research regarding JAK/STAT signaling and its contribution to renal disease is still ongoing in humans. Future studies are required to elucidate the potential role of JAK/STAT signaling inhibition as a therapeutic strategy in the attenuation of renal fibrosis.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Quinasas Janus / Enfermedades Renales Límite: Animals / Humans Idioma: En Revista: J Surg Res Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Quinasas Janus / Enfermedades Renales Límite: Animals / Humans Idioma: En Revista: J Surg Res Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos