Your browser doesn't support javascript.
loading
Aluminium-induced enhancement of ageing-related biochemical and electrophysiological parameters in rat brain regions.
Kaur, Jaspreet; Singh, Sangeeta; Sharma, Deepak; Singh, Rameshwar.
Afiliación
  • Kaur J; School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067.
Indian J Biochem Biophys ; 40(5): 330-9, 2003 Oct.
Article en En | MEDLINE | ID: mdl-22900327
We investigated alterations in the ageing-related parameters: multiple-unit action potentials, Na(+), K(+)-ATPase activity, glutathione-s-transferase (GST) activity, glutathione peroxidase (GPx) activity, lipid peroxidation and lipofuscin contents in the brain regions cerebral cortex, striatum, hippocampus and thalamus, resulting from the chronic administration of aluminium chloride (AlCl3) in drinking water to rats of 6 and 12 months of age. Aluminium treatment significantly depressed Na(+), K(+)-ATPase, GST and GPx activities, elevated lipid peroxidation and lipofuscin contents, and produced intense epileptiform activity in the electroencephalograms of the studied brain regions together with a concomitant increase in the multiple-unit action potentials (MUA) indicating a vigorous neuronal epileptic hyperactivity. Taken together the aluminium-induced alterations in these parameters are indicative of an accelerated ageing process.
Asunto(s)
Buscar en Google
Banco de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Fenómenos Electrofisiológicos / Aluminio Límite: Animals Idioma: En Revista: Indian J Biochem Biophys Año: 2003 Tipo del documento: Article
Buscar en Google
Banco de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Fenómenos Electrofisiológicos / Aluminio Límite: Animals Idioma: En Revista: Indian J Biochem Biophys Año: 2003 Tipo del documento: Article