Baroreflex control of renal sympathetic nerve activity in mice with cardiac hypertrophy.
Auton Neurosci
; 170(1-2): 62-5, 2012 Sep 25.
Article
en En
| MEDLINE
| ID: mdl-22921489
ABSTRACT
Altered renal sympathetic nerve activity (RSNA) plays a major role in the progression of cardiac hypertrophy. We aimed to evaluate the baroreflex control of RSNA in mice with cardiac hypertrophy. Swiss Webster mice were treated with isoproterenol (15 µg/g/day, s.c.) or vehicle and the baroreflex evaluation was performed by measuring changes in RSNA in response to changes in arterial pressure. The maximal gain of the reflex changes in RSNA was reduced in isoproterenol-treated animals (1.39 ± 0.08%/mm Hg) in comparison with vehicle-treated animals (1.77 ± 0.10%/mm Hg). Therefore, we can conclude that cardiac hypertrophy led to a reduced sensitivity of baroreflex control of RSNA.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sistema Nervioso Simpático
/
Cardiomegalia
/
Barorreflejo
/
Riñón
Límite:
Animals
Idioma:
En
Revista:
Auton Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Brasil