Inner ear anomalies seen on CT images in people with Down syndrome.
Pediatr Radiol
; 42(12): 1449-55, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-22936282
ABSTRACT
BACKGROUND:
Although dysplasia of inner ear structures in Down syndrome has been reported in several histopathological studies, the imaging findings have not been widely studied.OBJECTIVE:
To evaluate the prevalence and clinical significance of inner ear anomalies detected on CT images in patients with Down syndrome. MATERIALS ANDMETHODS:
The temporal bone CT images of patients with Down syndrome were assessed for inner ear anomalies; clinical notes and audiograms were reviewed for hearing loss. Logistic regression models were employed to identify which CT findings were associated with sensorineural hearing loss (SNHL).RESULTS:
Inner ear anomalies were observed in 74.5% (38/51) of patients. Malformed bone islands of lateral semicircular canal (LSCC), narrow internal auditory canals (IACs), cochlear nerve canal stenoses, semicircular canal dehiscence (SCCD), and enlarged vestibular aqueducts were detected in 52.5% (53/101), 24.5% (25/102), 21.4% (21/98), 8.8% (9/102) and 2% (2/101) of patients' ears, respectively. IAC stenosis had the highest odds ratio (OR = 5.37, 95% CI 1.0-28.9, P = 0.05) for SNHL.CONCLUSION:
Inner ear anomalies occurred in 74.5% of our population, with malformed (<3 mm) bone island of LSCC being the most common (52.5%) anomaly. Narrow IAC was seen in 24.5% of patients with Down syndrome and in 57.1% of ears with SNHL. High-resolution CT is a valuable for assessing the cause of hearing loss in people with Down syndrome.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tomografía Computarizada por Rayos X
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Síndrome de Down
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Pérdida Auditiva Sensorineural
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Oído Interno
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Pediatr Radiol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos