Using metabolomics to assess myocardial metabolism and energetics in heart failure.
J Mol Cell Cardiol
; 55: 12-8, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-22982115
ABSTRACT
There is a long history of investigation into the metabolism of the failing heart. Congestive heart failure is marked both by severe disruptions in myocardial energy supply and an inability of the heart to efficiently uptake and oxidize fuels. Despite the many advancements in our understanding, there are still even more outstanding questions in the field. Metabolomics has the power to assist our understanding of the metabolic derangements which accompany myocardial dysfunction. Metabolomic investigations in animal models of heart failure have already highlighted several novel, potentially important pathways of substrate selection and toxicity. Metabolomic biomarker studies in humans, already successfully applied to other forms of cardiovascular disease, have the potential to improve diagnosis and patient care. This article is part of a Special Issue entitled "Focus on Cardiac Metabolism".
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Metabolismo Energético
/
Metabolómica
/
Insuficiencia Cardíaca
/
Miocardio
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Mol Cell Cardiol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos