Temporal expression analysis of angiogenesis-related genes in brain development.
Vasc Cell
; 4(1): 16, 2012 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-23020941
ABSTRACT
BACKGROUND:
The current knowledge on molecular pathogenesis of cerebral vascular malformations (CVM), which are believed to arise during development, is very limited. To unravel the molecular mechanisms involved in CVMs, a detailed understanding of the brain vascular development at molecular level is crucial. In this study, we aimed to explore the temporal and comparative expression profile of angiogenesis-related genes in the establishment of brain vasculature.METHODS:
Expression of a total of 113 angiogenesis-related genes during murine brain development has been analyzed using low-density array systems designed for angiogenesis-related genes. Bai1 (brain specific angiogenesis inhibitor-1), a recently identified novel anti-angiogenic gene, has been selected for further characterization.RESULTS:
We found that 62 out of 113 analyzed genes have expression in brain development at varying levels. Nineteen of these were differentially expressed between embryonic and postnatal stages (>1.5 fold). Bai1 is strongly expressed on growing blood vessels of cerebral cortex and hippocampus, partially expressed in the lateral regions of striatum, but mostly absent on the thalamus.CONCLUSION:
By showing the comparative expression analysis of angiogenesis-related genes throughout brain development, the data presented here will be a crucial addition to further functional studies on cerebrovascular research.
Texto completo:
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Banco de datos:
MEDLINE
Idioma:
En
Revista:
Vasc Cell
Año:
2012
Tipo del documento:
Article
País de afiliación:
Turquía