Acute vasoreactivity testing with nicardipine in patients with pulmonary arterial hypertension.
J Pharmacol Sci
; 120(3): 206-12, 2012.
Article
en En
| MEDLINE
| ID: mdl-23117888
Acute vasoreactivity testing for patients with pulmonary arterial hypertension (PAH) has been reported to be useful to identify patients with sustained beneficial response to oral calcium-channel blockers (CCBs), but there is a risk of exacerbation during the testing with oral CCBs. Therefore, we developed a testing method utilizing intravenous nicardipine, a short-acting CCB, and examined the safety and usefulness of acute vasoreactivity testing with nicardipine in PAH patients. Acute vasoreactivity testing with nicardipine was performed in 65 PAH patients. Nicardipine was administered by short-time continuous infusion (1 µg·kg⻹·min⻹ for 5 min and 2 µg·kg⻹·min⻹ for 5 min) followed by bolus injection (5 µg/kg). Hemodynamic responses were continuously measured using a right heart catheter. Acute responders were defined as patients who showed a decrease in mean pulmonary artery pressure of at least 10 mmHg to an absolute level below 40 mmHg with preserved or increased cardiac output. Two acute responders and sixty-three non-acute responders were identified. There was no hemodynamic instability requiring additional inotropic agents or death during the testing. Acute responders had good responses to long-term oral CCBs. The acute vasoreactivity testing with nicardipine might be safe and useful for identifying CCB responders in PAH patients.
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Banco de datos:
MEDLINE
Asunto principal:
Vasodilatación
/
Vasodilatadores
/
Bloqueadores de los Canales de Calcio
/
Nicardipino
/
Monitoreo de Drogas
/
Hipertensión Pulmonar
/
Antihipertensivos
Tipo de estudio:
Evaluation_studies
/
Guideline
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Pharmacol Sci
Asunto de la revista:
FARMACOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Japón