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Testing of human papillomavirus in lung cancer and non-tumor lung tissue.
Galvan, Antonella; Noci, Sara; Taverna, Francesca; Lombardo, Claudia; Franceschi, Silvia; Pastorino, Ugo; Dragani, Tommaso A.
Afiliación
  • Galvan A; Department of Predictive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Via Amadeo 42, Milan 20133, Italy.
BMC Cancer ; 12: 512, 2012 Nov 12.
Article en En | MEDLINE | ID: mdl-23140419
BACKGROUND: Risk factors for lung cancer, such as cigarette smoking, environmental pollution, asbestos, and genetic determinants, are well-known, whereas involvement of the human papillomavirus (HPV) is still unclear. METHODS: We examined a series of 100 lung cancer patients from Italy and the UK for the presence of HPV DNA in both lung tumor specimens and adjacent non-tumoral specimens from the same patients. Thirty-five of the most clinically relevant HPV types were assayed using PCR amplification of the highly conserved L1 region of the viral genome followed by hybridization with specific probes. RESULTS: No HPV was detected in tumor specimens nor in normal lung tissue of any patient. CONCLUSIONS: These data indicate that, in this Western series, HPV is not associated with the risk of lung cancer. Our findings will help refine estimates of lung cancer risk in patients affected by a common viral infection involved in other types of human cancer.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN Viral / Carcinoma / Infecciones por Papillomavirus / Neoplasias Pulmonares Tipo de estudio: Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2012 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN Viral / Carcinoma / Infecciones por Papillomavirus / Neoplasias Pulmonares Tipo de estudio: Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2012 Tipo del documento: Article País de afiliación: Italia