Performance of cancer cluster Q-statistics for case-control residential histories.
Spat Spatiotemporal Epidemiol
; 3(4): 297-310, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-23149326
ABSTRACT
Few investigations of health event clustering have evaluated residential mobility, though causative exposures for chronic diseases such as cancer often occur long before diagnosis. Recently developed Q-statistics incorporate human mobility into disease cluster investigations by quantifying space- and time-dependent nearest neighbor relationships. Using residential histories from two cancer case-control studies, we created simulated clusters to examine Q-statistic performance. Results suggest the intersection of cases with significant clustering over their life course, Q(i), with cases who are constituents of significant local clusters at given times, Q(it), yielded the best performance, which improved with increasing cluster size. Upon comparison, a larger proportion of true positives were detected with Kulldorf's spatial scan method if the time of clustering was provided. We recommend using Q-statistics to identify when and where clustering may have occurred, followed by the scan method to localize the candidate clusters. Future work should investigate the generalizability of these findings.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Estudios de Casos y Controles
/
Análisis por Conglomerados
/
Dinámica Poblacional
/
Análisis Espacial
/
Neoplasias
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
America do norte
/
Europa
Idioma:
En
Revista:
Spat Spatiotemporal Epidemiol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos