Combination of phage display and molecular grafting generates highly specific tumor-targeting miniproteins.
Angew Chem Int Ed Engl
; 51(52): 13136-9, 2012 Dec 21.
Article
en En
| MEDLINE
| ID: mdl-23150222
ABSTRACT
Frankenstein's peptide the grafting of the binding domain from miniprotein Min-23 into the sunflower trypsin inhibitor (SFTI-I) peptide scaffold preserved its in vitro and in vivo binding specificity and proteolytic stability. The combination of these peptides was shown to be tumor-specific with a good binding affinity for delta-like ligand 4 (Dll4) protein. The use of SFTI-I as a peptide scaffold is ideal for hit-to-lead development.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Inhibidores de Tripsina
Límite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2012
Tipo del documento:
Article
País de afiliación:
Alemania