Meta-analysis of the relation between the VDR gene TaqIpolymorphism and genetic susceptibility to prostate cancer in Asian populations.
Asian Pac J Cancer Prev
; 13(9): 4441-4, 2012.
Article
en En
| MEDLINE
| ID: mdl-23167358
ABSTRACT
BACKGROUND:
Polymorphisms of the Taq I gene have been associated with prostate cancer risk.METHODS:
We applied a fixed-effects model to combine odds ratios (ORs) and 95% confidence intervals (95% CI). The Egger's test was carried out to evaluate potential publication bias.RESULTS:
A total of 10 case-control studies enrolling 1,141 prostate cancer patients and 1,685 controls were included in this meta-analysis. Compared with the T allele, the OR for the C allele was 0.81 (0.70-0.94). The ORs for CT and CC+CT genotypes were 0.86 (0.74-1.01) and 0.84 (0.73-0.97) compared to wide type genotype (homozygote TT).CONCLUSIONS:
The present meta-analysis suggests that the TF gene Taq I polymorphism may reduce the prostate cancer risk in Asian populations.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Receptores de Calcitriol
/
Predisposición Genética a la Enfermedad
/
Pueblo Asiatico
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
/
Male
Idioma:
En
Revista:
Asian Pac J Cancer Prev
Asunto de la revista:
NEOPLASIAS
Año:
2012
Tipo del documento:
Article
País de afiliación:
China