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Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser.
Redecke, Lars; Nass, Karol; DePonte, Daniel P; White, Thomas A; Rehders, Dirk; Barty, Anton; Stellato, Francesco; Liang, Mengning; Barends, Thomas R M; Boutet, Sébastien; Williams, Garth J; Messerschmidt, Marc; Seibert, M Marvin; Aquila, Andrew; Arnlund, David; Bajt, Sasa; Barth, Torsten; Bogan, Michael J; Caleman, Carl; Chao, Tzu-Chiao; Doak, R Bruce; Fleckenstein, Holger; Frank, Matthias; Fromme, Raimund; Galli, Lorenzo; Grotjohann, Ingo; Hunter, Mark S; Johansson, Linda C; Kassemeyer, Stephan; Katona, Gergely; Kirian, Richard A; Koopmann, Rudolf; Kupitz, Chris; Lomb, Lukas; Martin, Andrew V; Mogk, Stefan; Neutze, Richard; Shoeman, Robert L; Steinbrener, Jan; Timneanu, Nicusor; Wang, Dingjie; Weierstall, Uwe; Zatsepin, Nadia A; Spence, John C H; Fromme, Petra; Schlichting, Ilme; Duszenko, Michael; Betzel, Christian; Chapman, Henry N.
Afiliación
  • Redecke L; Joint Laboratory for Structural Biology of Infection and Inflammation, Institute of Biochemistry and Molecular Biology, University of Hamburg, and Institute of Biochemistry, University of Lübeck, at Deutsches Elektronen-Synchrotron (DESY), Notkestrasse 85, 22607 Hamburg, Germany.
  • Nass K; German Centre for Infection Research, University of Lübeck, 23538 Lübeck, Germany.
  • DePonte DP; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • White TA; Department of Physics, University of Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany.
  • Rehders D; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Barty A; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Stellato F; Joint Laboratory for Structural Biology of Infection and Inflammation, Institute of Biochemistry and Molecular Biology, University of Hamburg, and Institute of Biochemistry, University of Lübeck, at Deutsches Elektronen-Synchrotron (DESY), Notkestrasse 85, 22607 Hamburg, Germany.
  • Liang M; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Barends TRM; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Boutet S; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Williams GJ; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.
  • Messerschmidt M; Max Planck Advanced Study Group, Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Seibert MM; Linac Coherent Light Source, Stanford Linear Accelerator Center (SLAC) National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA.
  • Aquila A; Linac Coherent Light Source, Stanford Linear Accelerator Center (SLAC) National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA.
  • Arnlund D; Linac Coherent Light Source, Stanford Linear Accelerator Center (SLAC) National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA.
  • Bajt S; Linac Coherent Light Source, Stanford Linear Accelerator Center (SLAC) National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA.
  • Barth T; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Bogan MJ; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
  • Caleman C; Photon Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Chao TC; Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Strasse 4, 72076 Tübingen, Germany.
  • Doak RB; Photon Ultrafast Laser Science and Engineering (PULSE) Institute, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA.
  • Fleckenstein H; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Frank M; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
  • Fromme R; Department of Physics, Arizona State University, Tempe, AZ 85287, USA.
  • Galli L; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Grotjohann I; Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550, USA.
  • Hunter MS; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
  • Johansson LC; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Kassemeyer S; Department of Physics, University of Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany.
  • Katona G; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
  • Kirian RA; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
  • Koopmann R; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
  • Kupitz C; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.
  • Lomb L; Max Planck Advanced Study Group, Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Martin AV; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
  • Mogk S; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Neutze R; Department of Physics, Arizona State University, Tempe, AZ 85287, USA.
  • Shoeman RL; Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Strasse 4, 72076 Tübingen, Germany.
  • Steinbrener J; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
  • Timneanu N; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.
  • Wang D; Max Planck Advanced Study Group, Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Weierstall U; Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Zatsepin NA; Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Strasse 4, 72076 Tübingen, Germany.
  • Spence JCH; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
  • Fromme P; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.
  • Schlichting I; Max Planck Advanced Study Group, Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Duszenko M; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.
  • Betzel C; Max Planck Advanced Study Group, Center for Free-Electron Laser Science (CFEL), DESY, Notkestrasse 85, 22607 Hamburg, Germany.
  • Chapman HN; Department of Cell and Molecular Biology, Uppsala University, Husargatan 3, SE-75124 Uppsala, Sweden.
Science ; 339(6116): 227-230, 2013 Jan 11.
Article en En | MEDLINE | ID: mdl-23196907
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trypanosoma brucei brucei / Catepsina B / Proteínas Protozoarias Límite: Animals Idioma: En Revista: Science Año: 2013 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trypanosoma brucei brucei / Catepsina B / Proteínas Protozoarias Límite: Animals Idioma: En Revista: Science Año: 2013 Tipo del documento: Article País de afiliación: Alemania