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The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.
Plowman, G D; Green, J M; McDonald, V L; Neubauer, M G; Disteche, C M; Todaro, G J; Shoyab, M.
Afiliación
  • Plowman GD; Oncogen, Seattle, Washington 98121.
Mol Cell Biol ; 10(5): 1969-81, 1990 May.
Article en En | MEDLINE | ID: mdl-2325643
We have isolated the gene for a novel growth regulator, amphiregulin (AR), that is evolutionarily related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). AR is a bifunctional growth modulator: it interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. The 84-amino-acid mature protein is embedded within a 252-amino-acid transmembrane precursor, an organization similar to that of the TGF-alpha precursor. Human placenta and ovaries were found to express significant amounts of the 1.4-kilobase AR transcript, implicating AR in the regulation of normal cell growth. In addition, the AR gene was localized to chromosomal region 4q13-4q21, a common breakpoint for acute lymphoblastic leukemia.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glicoproteínas / Sustancias de Crecimiento / Péptidos y Proteínas de Señalización Intercelular Límite: Humans Idioma: En Revista: Mol Cell Biol Año: 1990 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glicoproteínas / Sustancias de Crecimiento / Péptidos y Proteínas de Señalización Intercelular Límite: Humans Idioma: En Revista: Mol Cell Biol Año: 1990 Tipo del documento: Article