Collective cell migration of epithelial and mesenchymal cells.
Cell Mol Life Sci
; 70(19): 3481-92, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23314710
ABSTRACT
Directional cell migration is required for proper embryogenesis, immunity, and healing, and its underpinning regulatory mechanisms are often hijacked during diseases such as chronic inflammations and cancer metastasis. Studies on migratory epithelial tissues have revealed that cells can move as a collective group with shared responsibilities. First thought to be restricted to proper epithelial cell types able to maintain stable cell-cell junctions, the field of collective cell migration is now widening to include cooperative behavior of mesenchymal cells. In this review, we give an overview of the mechanisms driving collective cell migration in epithelial tissues and discuss how mesenchymal cells can cooperate to behave as a collective in the absence of bona fide cell-cell adhesions.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Comunicación Celular
/
Movimiento Celular
/
Células Epiteliales
/
Células Madre Mesenquimatosas
Límite:
Animals
Idioma:
En
Revista:
Cell Mol Life Sci
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido