Octreotide-induced hepatitis in a child with persistent hyperinsulinemia hypoglycemia of infancy.
J Pediatr Endocrinol Metab
; 26(1-2): 179-82, 2013.
Article
en En
| MEDLINE
| ID: mdl-23327813
ABSTRACT
Persistent hyperinsulinemic hypoglycemia of infancy (PHHI), the most common cause of persistent hypoglycemia in the neonatal period and infancy, is a genetic disorder characterized by abnormal regulation of insulin secretion. Octreotide, a somatostatin analog, is often used as a second-line treatment when diazoxide therapy fails to control hypoglycemia. We report herein a rare development of octreotide-induced hepatitis following prolonged treatment for PHHI in an infant. Octreotide-induced hepatitis may occur mostly when high doses are given, or when dosing is increased. This warrants routine examination of liver function. When hepatitis develops, prompt cessation of octreotide therapy will probably result in subsequent resolution.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Octreótido
/
Hiperinsulinismo Congénito
/
Enfermedad Hepática Inducida por Sustancias y Drogas
Límite:
Humans
/
Infant
/
Male
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Israel