Larvicidal activity and click synthesis of 2-alkoxyl-2-(1,2,3-triazole-1- yl)acetamide library.
Comb Chem High Throughput Screen
; 16(6): 484-93, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23360208
ABSTRACT
Heterogeneous copper-in-charcoal-catalyzed click synthesis in 96-well polypropylene filter plates is an efficient method for the rapid generation of sufficient pure 2-alkoxyl-2-(1,2,3-triazole-1-yl) acetamide derivatives library by simple filtration, which directly assay the products for larvicidal activity against mosquitoes. In this procedure, copper nanoparticles on charcoal were arrayed into each well on a 96-well plate, reagents were delivered using a pipette gun, and a constant temperature shaker bath was used to complete the click reaction in 24-72 hours under temperature-controlled conditions. The results of bioassays indicated that the target compounds possessed excellent larvacidal activities against mosquitoes. In particular, the larvacidal activities against mosquitoes of compounds 8[2,3] and 8[7,1] at 2 µg.mL⻹ were 100% and 73% respectively.
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Banco de datos:
MEDLINE
Asunto principal:
Triazoles
/
Bibliotecas de Moléculas Pequeñas
/
Química Clic
/
Insecticidas
/
Acetamidas
/
Culicidae
Límite:
Animals
Idioma:
En
Revista:
Comb Chem High Throughput Screen
Asunto de la revista:
BIOLOGIA MOLECULAR
/
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
China