Possible association between suicide committed under influence of ethanol and a variant in the AUTS2 gene.
PLoS One
; 8(2): e57199, 2013.
Article
en En
| MEDLINE
| ID: mdl-23437340
ABSTRACT
BACKGROUND:
rs6943555 in AUTS2 has been shown to modulate ethanol consumption. We hypothesized that rs6943555 might be associated with completed suicide.METHODS:
We genotyped rs6943555 in 625 completed suicides and 3861 controls using real-time TaqMan Allelic Discrimination Assay. All individuals were Polish Caucasians.RESULTS:
We detected an association between suicide and rs6943555 A allele (ORâ=â1.17, Pâ=â0.018 for allelic comparison, ORâ=â1.24, Pâ=â0.013 for dominant, and ORâ=â1.18, Pâ=â0.020 for co-dominant model of inheritance). The association remained significant after adjusting for age and gender (co-dominant Pâ=â0.002 and dominant model Pâ=â0.001). After stratifying suicides according to blood ethanol concentration (BAC≤ 20 mg/dl and BAC > 20 mg/dl) the association remained significant only for cases who committed suicide under influence of alcohol (co-dominant OR â=â 1.37, Pâ=â0.004 and dominant model ORâ=â1.45, Pâ=â0.006). To validate this finding we genotyped another cohort of 132 cases. We reproduced the association between rs6943555 A allele and suicide under influence of ethanol (allelic comparison ORâ=â1.55, Pâ=â0.023; co-dominant ORâ=â1.54, Pâ=â0.031; dominant model ORâ=â1.84, Pâ=â0.015). Analyzing pooled suicides with BAC >20 mg/dl (Nâ=â300) we found the association of rs6943555 A allele not only vs. controls (allelic ORâ=â1.41, Pâ=â0.00029) but also vs. cases with BAC ≤ 20 mg/dl (Nâ=â449, allelic ORâ=â1.33, Pâ=â0.019).CONCLUSIONS:
In our study rs6943555 A allele is associated with suicide committed after drinking ethanol shortly before death. The rs6943555 A allele may be linked to adverse emotional reaction to ethanol, which could explain the association with lower consumption in general population as well as the predisposition to suicide under influence of ethanol.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Suicidio
/
Consumo de Bebidas Alcohólicas
/
Proteínas
/
Polimorfismo de Nucleótido Simple
/
Alelos
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Polonia