Robust Bayesian inference for multivariate longitudinal data by using normal/independent distributions.
Stat Med
; 32(22): 3812-28, 2013 Sep 30.
Article
en En
| MEDLINE
| ID: mdl-23494809
ABSTRACT
Many randomized clinical trials collect multivariate longitudinal measurements in different scales, for example, binary, ordinal, and continuous. Multilevel item response models are used to evaluate the global treatment effects across multiple outcomes while accounting for all sources of correlation. Continuous measurements are often assumed to be normally distributed. But the model inference is not robust when the normality assumption is violated because of heavy tails and outliers. In this article, we develop a Bayesian method for multilevel item response models replacing the normal distributions with symmetric heavy-tailed normal/independent distributions. The inference is conducted using a Bayesian framework via Markov Chain Monte Carlo simulation implemented in BUGS language. Our proposed method is evaluated by simulation studies and is applied to Earlier versus Later Levodopa Therapy in Parkinson's Disease study, a motivating clinical trial assessing the effect of Levodopa therapy on the Parkinson's disease progression rate.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ensayos Clínicos Controlados Aleatorios como Asunto
/
Análisis Multivariante
/
Estudios Longitudinales
/
Modelos Estadísticos
/
Teorema de Bayes
Tipo de estudio:
Clinical_trials
/
Health_economic_evaluation
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Stat Med
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos