Differential propensity of citrate- and polyethylene glycol-coated silver nanoparticles to bovine hemoglobin.
Toxicol Ind Health
; 31(8): 721-6, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-23546398
ABSTRACT
Propensity of two different silver nanoparticles (Ag-NPs) to bovine hemoglobin (BHb) was investigated by means of spectroscopic methods. We have combined spectrophotometric and calorimetric methods to show that there is no significant interaction between citrate-coated Ag-NPs and BHb at physiological pH and 20°C. However, our previous results show that polyethylene glycol-coated Ag-NPs strongly bind to Hb and effect on the secondary and tertiary structures of BHb. Thus, a suitable surface coating and modification of surface charge would increase the NPs safety and reduce adverse biological responses.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plata
/
Hemoglobinas
/
Ácido Cítrico
/
Nanopartículas del Metal
Límite:
Animals
Idioma:
En
Revista:
Toxicol Ind Health
Asunto de la revista:
MEDICINA OCUPACIONAL
/
TOXICOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Irán