Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis.
Int J Neurosci
; 123(11): 776-82, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-23659338
ABSTRACT
BACKGROUND:
Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system in which a higher oxidative stress may contribute to its pathogenesis. The aim of this study was to investigate the effect of coenzyme Q10 (CoQ10) supplementation on oxidative stress and antioxidant enzyme activity in patients with MS. MATERIALS ANDMETHODS:
We performed a randomized, double-blinded, placebo-controlled trail to determine the effect of CoQ10 supplement (500 mg/day, n = 24) versus placebo (controls, n = 24) for 12 weeks. Fasting blood samples were taken before and after a 12-week intervention to analyze malondialdehyde (MDA), total antioxidant capacity (TAC) and antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GPx)] activity.RESULTS:
Forty-five subjects with MS completed intervention study. After 12 weeks, CoQ10-treated patients had significant increase in SOD activity (p = 0.013); and decrease in MDA levels (P=0.003) compared with controls. Despite the significant effect of CoQ10 supplementation on plasma TAC (p = 0.010), no significant differences were found between the two groups. CoQ10 supplementation did not affect GPx activity.CONCLUSION:
Present study suggests that CoQ10 supplements at a dose of 500 mg/day can decrease oxidative stress and increase antioxidant enzyme activity in patients with relapsing-remitting MS.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ubiquinona
/
Estrés Oxidativo
/
Suplementos Dietéticos
/
Esclerosis Múltiple Recurrente-Remitente
/
Glutatión Peroxidasa
/
Antioxidantes
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int J Neurosci
Año:
2013
Tipo del documento:
Article