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[Experimental studies on pharmacokinetics of three components in Buyanghuanwu injection on base of total quantum statistical moment].
He, Fu-Yuan; Deng, Kai-Wen; Liu, Wen-Long; Shi, Ji-Lian; Wu, Yong; Liu, Wei; He, Qing-Ping; Li, Bo.
Afiliación
  • He FY; Department of Pharmaceutics, Hunan University of Traditional Chinese Medicine, Changsha 410208, China. pharmsharking@tom.com
Zhongguo Zhong Yao Za Zhi ; 38(2): 253-62, 2013 Jan.
Article en Zh | MEDLINE | ID: mdl-23672052
OBJECTIVE: To verify established the total quantum statistic moments model with astragaloside IV, paeoniflorin, tetramethylpyrazine in Buyanghuanwu injection, in order to establish a pharmacokinetic experimental method with multi-component traditional Chinese medicine (TCM) compound system. METHOD: The RP-HPLC was adopted, with the chromatographic column of C18, 4.6 mm x 250 mm, 5 microm. As for astragaloside IV, the ELSD detector was adopted with acetonitrile-water (35: 65) as the mobile phase at 1 mL x min(-1); the pressure of column was (15.0 +/- 0.408) MPa, the column temperature was 30 degrees C. Regarding paeoniflorin and tetramethylpyrazine, the detection of wavelengths was 254 nm, with acetonitrile-water (35:65) as the mobile phase at 1 mL x min(-1), the column pressure of (15.17 +/- 0.41) MPa. The pharmacokinetic parameters for single component were dealt with DAS and the total quantum statistical moment (TQSM) parameters were calculated using formulations. RESULT: All of the three components followed the two compartmental pharkacokinetic model (P < 0.01) in rats. Compared with the superimposed total concentration, each single component showed difference in parameters up to 10 000 times at most, whereas the RSD of TQSM parameters was 3.510%. The TQSM pharmacokinetic parameters of the three components in Buyanghuanwu injection showed that AUC(t), MRT(t), VRT(t), CL(t), V(t), were (119.8 +/- 27.20) g x min x L(-1), (210.0 +/- 54.49) min, (5.608 +/- 2.723) x 10(4) min2, (0.319 6 +/- 0.068 8) mL x min(-1) x kg(-1) and (64.12 +/- 8.243) mL x kg(-1), respectively, suggesting that the half-life time for the three components were (145.5 +/- 37.76) min and 95% of them were metabolized within 0-674. 2 min. CONCLUSION: The TQSM can be used to study pharmacokinetic parameters of multi-component TCM compound, because the method can characterize the pharmacokinetic regularity of quantum-time change in a multi-component system.
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Banco de datos: MEDLINE Asunto principal: Pirazinas / Saponinas / Triterpenos / Benzoatos / Hidrocarburos Aromáticos con Puentes / Medicamentos Herbarios Chinos / Modelos Estadísticos / Glucósidos Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Animals Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2013 Tipo del documento: Article País de afiliación: China
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Banco de datos: MEDLINE Asunto principal: Pirazinas / Saponinas / Triterpenos / Benzoatos / Hidrocarburos Aromáticos con Puentes / Medicamentos Herbarios Chinos / Modelos Estadísticos / Glucósidos Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Animals Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2013 Tipo del documento: Article País de afiliación: China