Celiac disease is not increased in women with hip fractures and low vitamin D levels.
J Nutr Health Aging
; 17(6): 562-5, 2013.
Article
en En
| MEDLINE
| ID: mdl-23732553
ABSTRACT
OBJECTIVE:
Celiac disease is associated with decreased bone density; however, the risk of fractures in celiac disease patients is unclear. We compared the prevalence of celiac disease between a group of women with hip fractures and a group of women undergoing elective joint replacement surgery and the association between celiac disease and vitamin D levels.METHODS:
Two hundred eight community dwelling and postmenopausal women were recruited from Boston, MA (n=81) and Baltimore, MD (n=127). We measured tissue transglutaminase IgA by ELISA to diagnose celiac disease and 25-hydroxyvitamin D (25(OH)D) levels by radioimmunoassay in both women with hip fractures (n=157) and a control group (n=51) of total hip replacement subjects from Boston. Subjects were excluded if they took any medications or had medical conditions that might affect bone.RESULTS:
Median serum 25(OH)D levels were significantly lower (p< 0.0001) in the hip fracture cohorts compared to the elective joint replacement cohort (14.1 ng/ml vs. 21.3 ng/ml, respectively). There were no differences in the percentage of subjects with a positive tissue transglutaminase in the women with hip fractures versus the control group (1.91% vs. 1.96%, respectively).CONCLUSION:
Vitamin D levels are markedly reduced in women with hip fractures, however hip fracture patients did not show a higher percentage of positive tissue transglutaminase levels compared with controls. These data suggest that routine testing for celiac disease among hip fracture patients may not be necessary in the absence of clinical signs and symptoms, although data from larger studies among hip fracture subjects are needed.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Deficiencia de Vitamina D
/
Enfermedad Celíaca
/
Fracturas de Cadera
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Prevalence_studies
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Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Nutr Health Aging
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
GERIATRIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos