Optical biopsy of benign and malignant tissue by time resolved spectroscopy.
Technol Cancer Res Treat
; 12(6): 559-63, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-23745786
ABSTRACT
Pathological condition of malignant tissue could be analyzed by spectral domain or time domain spectroscopy, the two being the complementary to each other in optical biopsy (OB) of cancer. This paper reports results of time resolved emission spectroscopy (TRS) of 24 excised tissue samples of breast and prostate (normal control = 12; benign = 4; malignant = 8), employing a 390 nm, 100 fs, Ti-Sapphire laser pulses.The fluorescence decay times were measured using streak camera and the resultant data were fitted for single and bi-exponential decays with reliability of 97%. Our results show the distinct difference between normal, benign and malignant tissues mostly due to the emission spectra of Nicotinamide Adenine Dinucleotide (NADH), Flavin Mononucleotide (FAD) and also due to the heterogeneity of micro environments associated with the diseased tissues. In this short report, fit is also shown that TRS of breast tissues are similar to those of prostate tissues.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Próstata
/
Neoplasias de la Próstata
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Neoplasias de la Mama
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Glándulas Mamarias Humanas
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Technol Cancer Res Treat
Asunto de la revista:
NEOPLASIAS
/
TERAPEUTICA
Año:
2013
Tipo del documento:
Article