Prognostic impact of VEGF and FLT-1 receptor expression in patients with locally advanced squamous cell carcinoma of the head and neck.
Strahlenther Onkol
; 189(8): 639-46, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23748230
ABSTRACT
BACKGROUND AND PURPOSE:
This study investigated the prognostic value of tumor cell expression of vascular endothelial growth factor (VEGF) and its receptor fms-related tyrosine kinase 1 (FLT-1) in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) who had been treated with adjuvant radiotherapy or radiochemotherapy. MATERIAL ANDMETHODS:
The impact of tumor cell VEGF and FLT-1 expression plus 11 additional factors on loco-regional control (LRC), metastases-free survival (MFS) and overall survival (OS) was retrospectively evaluated in 157 patients. The additional factors were age, gender, performance status, pre-radiotherapy (pre-RT) hemoglobin levels, tumor site, histologic grade, T-category, N-category, human papillomavirus (HPV) status, extent of resection and chemotherapy.RESULTS:
On multivariate analysis, improved LRC was significantly associated with an absence of VEGF expression (risk ratio, RR 5.02; p = 0.009), lower T-category (RR 2.00; p < 0.001), lower N-category (RR 3.75; p < 0.001) and pre-RT hemoglobin levels ≥ 12 g/dl (RR 2.20; p = 0.029). Improved MFS was significantly associated with an absence of VEGF expression (RR 7.46; p = 0.002), lower T-category (RR 1.97; p = 0.002), lower N-category (RR 3.29; p = 0.005) and a favorable tumor location (RR 1.34; p = 0.033); HPV positivity showed a trend towards improved MFS (RR 1.43; p = 0.09). Improved OS was significantly associated with an absence of VEFG expression (RR 3.22; p = 0.041), pre-RT hemoglobin levels ≥ 12 g/dl (RR 2.47; p = 0.009), lower T-category (RR 1.92; p < 0.001) and lower N-category (RR 3.39; p < 0.001). FLT-1 expression was significantly associated with LRC and OS in the univariate but not in the multivariate analysis.CONCLUSION:
VEGF expression proved to be an independent negative predictor for LRC, MFS and OS in patients treated for locally advanced SCCHN with adjuvant radiotherapy or radiochemotherapy. FLT-1 expression was not significant in multivariate analyses.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Escamosas
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Radioterapia Conformacional
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Receptor 1 de Factores de Crecimiento Endotelial Vascular
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Factor A de Crecimiento Endotelial Vascular
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Quimioradioterapia
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Neoplasias de Cabeza y Cuello
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Strahlenther Onkol
Asunto de la revista:
NEOPLASIAS
/
RADIOTERAPIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania