Enantioselective fluoroamination: 1,4-addition to conjugated dienes using anionic phase-transfer catalysis.

Shunatona, Hunter P; Früh, Natalja; Wang, Yi-Ming; Rauniyar, Vivek; Toste, F Dean

Shunatona, Hunter P; Früh, Natalja; Wang, Yi-Ming; Rauniyar, Vivek; Toste, F Dean.

Afiliación

Shunatona HP; Department of Chemistry, University of California-Berkeley, Latimer Hall, Berkeley, CA, USA.

Angew Chem Int Ed Engl ; 52(30): 7724-7, 2013 Jul 22.

Article en En | MEDLINE | ID: mdl-23766145

ABSTRACT

ABSTRACT

Chiral-anion phase-transfer catalysis (PTC) has been applied towards the enantioselective fluorocyclization reactions of 1,3-dienes. The method affords unprecedented fluorinated benz[f]isoquinoline and octahydroisoquinoline products in high yields and up to 96 % ee. New fluorinated amine reagents outperformed Selectfluor in the desired transformation.

Palabras clave

amination; asymmetric catalysis; cyclization; fluorine; phase-transfer catalysis

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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2013 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2013 Tipo del documento: Article País de afiliación: Estados Unidos