Experience in integrating ALK testing and crizotinib into the routine treatment of patients with non-small cell lung cancer.
Onkologie
; 36(6): 342-7, 2013.
Article
en En
| MEDLINE
| ID: mdl-23774148
ABSTRACT
BACKGROUND:
Crizotinib, an inhibitor of the anaplastic lymphoma kinase (ALK), is approved since 2012 in Switzerland for use in ALK-rearranged advanced pretreated non-small cell lung cancer (NSCLC). PATIENTS ANDMETHODS:
Here we describe our own experience with crizotinib and ALK testing via fluorescence in-situ hybridization (FISH) in the first 10 ALK-positive patients who were treated in central Switzerland in 2011 on a compassionate use basis.RESULTS:
We have demonstrated that FISH testing for ALK can be performed simultaneously with other diagnostic procedures, providing oncologists with results in a timely manner to make informed decisions about patient treatment. The majority of our patients treated with crizotinib had a clinical benefit, and the drug was tolerated well.CONCLUSION:
The clinical development of crizotinib has been extremely rapid. Nonetheless, by the time crizotinib was approved, many centers including our own had local testing in place and clinical experience with the drug. This emphasizes the importance of broad clinical studies and compassionate use programs in oncology.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pirazoles
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Piridinas
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Biomarcadores de Tumor
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Proteínas Tirosina Quinasas Receptoras
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Carcinoma de Pulmón de Células no Pequeñas
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Neoplasias Pulmonares
Tipo de estudio:
Diagnostic_studies
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Prognostic_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Onkologie
Año:
2013
Tipo del documento:
Article
País de afiliación:
Suiza