Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: virtual screening and functional testing identify novel small molecule therapeutics of hypertension.
Bioorg Med Chem
; 21(18): 5855-69, 2013 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-23916146
Palabras clave
3D; ASA; AchR; BP; CHGA; CST; Catestatin; DBP; DSI; Data Sciences International (St. Paul, MN); HR; Hypertension; Molecular database screening; Molecular database search; Molecular fingerprint; NMR; Pharmacophore; Pharmacophore annotation; SBP; SEM; Similarity clustering; acetylcholine receptor; blood pressure; catestatin; chromogranin A; diastolic blood pressure; heart rate; nuclear magnetic resonance; standard error of the mean; systolic blood pressure; three-dimensional; water-accessible surface area
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Catecolaminas
/
Cromogranina A
/
Antihipertensivos
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos