Cartilage to bone transitions in health and disease.
J Endocrinol
; 219(1): R1-R12, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23959079
ABSTRACT
Aberrant redeployment of the 'transient' events responsible for bone development and postnatal longitudinal growth has been reported in some diseases in what is otherwise inherently 'stable' cartilage. Lessons may be learnt from the molecular mechanisms underpinning transient chondrocyte differentiation and function, and their application may better identify disease aetiology. Here, we review the current evidence supporting this possibility. We firstly outline endochondral ossification and the cellular and physiological mechanisms by which it is controlled in the postnatal growth plate. We then compare the biology of these transient cartilaginous structures to the inherently stable articular cartilage. Finally, we highlight specific scenarios in which the redeployment of these embryonic processes may contribute to disease development, with the foresight that deciphering those mechanisms regulating pathological changes and loss of cartilage stability will aid future research into effective disease-modifying therapies.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Desarrollo Óseo
/
Enfermedades Óseas
/
Condrocitos
Límite:
Humans
Idioma:
En
Revista:
J Endocrinol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido