Antitrypanosomal triterpenoid with an ε-lactone E-ring from Salvia urmiensis.
J Nat Prod
; 76(9): 1806-9, 2013 Sep 27.
Article
en En
| MEDLINE
| ID: mdl-24007549
ABSTRACT
A new triterpenoid, urmiensolide (1), was isolated from Salvia urmiensis. The structure was elucidated by a combination of 1D and 2D NMR, HRESIMS, and X-ray crystallographic analyses. The absolute configuration was established by comparison of experimental and simulated ECD spectra. Urmiensolide is the first pentacyclic triterpenoid bearing a ε-lactone E-ring. The compound showed in vitro antitrypanosoal activity with an IC50 value of 5.6 µM against the Trypanosoma brucei rhodesiense STIB 900 strain and a selectivity index of 33. A possible biosynthetic pathway of 1 from α-amyrin is proposed.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Triterpenos
/
Salvia
/
Lactonas
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Año:
2013
Tipo del documento:
Article
País de afiliación:
Irán